Beale, who has failed to overcome a hamstring injury this week, said on Twitter Saturday: "Thanks everyone for their support. Unfortunately been ruled out (sic).
"I've got faith in the boys who have got the opportunity."
Beale's unavailability means that utility Adam Ashley-Cooper will move to the full-back position, with Anthony Fainga'a promoted from the bench to outside-centre alongside Pat McCabe.
Rob Horne, who fractured his cheekbone against the USA three weeks ago, joins the seven-man replacements bench. (AFP)